Re: aromatase inhibitors
From: Anonymo (anonymous@obgyn.net)
Wed Jan 15 11:51:32 2003
Just a note about this AstraZeneca, if they are the ones who make
aromatase inhibitors.
AstraZeneca is also the company that manufacturers Zoladex, a GnRH
agonist,
the equivalent of Lupron. They are being sued by the government for
giving
illegal kickbacks and other lucrative incentives to doctors for pushing
their drug Zoladex to treat prostate cancer (it's now also used for
endometriosis).
See this article:
http://www.washingtonpost.com/wp-dyn/articles/A41546-2002Sep19.html
So just my personal opinion -- I would be a little skeptical of any of
their
drugs. As Dr. Cook points out in the article listed below, we do not
yet
know if aromatase inhibitors produce an acceptable level of side
effects.
They work similarly to GnRH agonists like Lupron, except they are
supposed
to be more effective. This also means they are more powerful. So I
would
be worried that they would have just as many side effects if not more.
This is just my opinion -- obviously I have never tried them.
At Wed, 15 Jan 2003, anonymous wrote:
>
>I have some info, I hope this helps. Aromatase inhibitors have been
>used in reproductive illnesses for a long time and are gaining a lot of
>popularity in the treatment of Endo.
>
>You can contact Dr. Bulun directly to go right to the key info at...
>
>Serdar E. Bulun, MD
>Director, Division of Reproductive Endocrinology
>Departments of Obstetrics and Gynecology and Molecular Genetics
>University of Illinois at Chicago
>820 S. Wood St., M/C 808
>Chicago, IL 60612
>Tel: (312) 996-8197
>Fax: (312) 996-4238
>(this is public information, don't worry...I'm not giving out top secret
>contact details =)
>
>The ERC has a hard copy transcript and a VHS tape of in-depth
>presentations by him, also. http://www.endocenter.org
>
>Dr. Cook has info on his site at: http://www.drcook.com/adca7.html
>
>The SGI 2002 Conference Report can be found on Medscape at:
>www.medscape.com/viewarticle/431591_4?WebLogicSession=PiWi99drIowVtusXq6gavcrjmDu2Af4SWWWB2HIIrpD6cfL5WRZS|-792488052100904750/184161392/6/7001/7001/7002/7002/7001/-1
>
>OBGYN.net article: http://www.obgyn.net/endo/articles/cook_0827.htm
>
>There is a live broadcast (may not be active any longer) at:
>http://webevents.broadcast.com/Endometriosis0524/
>
>A bit of info: http://www.wordplay.org/endometriosis/
>articles/futuretreatment.shtml
>
>News article: http://www.wtajtv.com/health/endotrea.html
>
>IAS article: http://www.adhesions.org/Links/Patient/endo.htm
>
>Check w/AstraZeneca's corporate site for more info; they are the ones
>who make the commercially available Aromatase Inhibitors. I THINK the
>site is astrazeneca.com, but I could be wrong.
>
>Also check Medline for the following citation abstracts, or see if maybe
>your doc, or local library even, has copies...some are new, some are
>older, some are repetitive, all are interesting...
>
>Yang S, Fang Z, Suzuki T, et al.
>Regulation of aromatase P450 expression in endometriotic and endometrial
>stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased
>C/EBPbeta in endometriosis is associated with overexpression of
>aromatase.
>J Clin Endocrinol Metab (United States), May 2002, 87(5) p2336-45
>
>Fang Z, Yang S, Gurates B, et al.
>Genetic or enzymatic disruption of aromatase inhibits the growth of
>ectopic uterine tissue.
>J Clin Endocrinol Metab (United States), Jul 2002, 87(7) p3460-6
>
>Takayama K, Bulun SE
>Endometriosis and aromatase inhibitor
>Nippon Rinsho (Japan), Jan 2001, 59 Suppl 1 p157-60
>
>Bulun SE, Zeitoun KM, Takayama K, et al.
>Molecular basis for treating endometriosis with aromatase inhibitors.
>Hum Reprod Update (England), Sep-Oct 2000, 6(5) p413-8
>
>Bulun SE, Zeitoun KM, Takayama K, et al.
>Aromatase as a therapeutic target in endometriosis.
>Trends Endocrinol Metab (United States), Jan-Feb 2000, 11(1) p22-7
>
>Kitawaki J, Kusuki I, Koshiba H, et al.
>Detection of aromatase cytochrome P-450 in endometrial biopsy specimens
>as a diagnostic test for endometriosis.
>Fertil Steril (United States), Dec 1999, 72(6) p1100-6
>
>Zeitoun KM, Bulun SE
>Aromatase: a key molecule in the pathophysiology of endometriosis and a
>therapeutic target.
>Fertil Steril (United States), Dec 1999, 72(6) p961-9
>
>Kitawaki J, Kusuki I, Koshiba H, et al.
>Detection of aromatase cytochrome P-450 in endometrial biopsy specimens
>as a diagnostic test for endometriosis.
>Fertil Steril (United States), Dec 1999, 72(6) p1100-6
>
>Zeitoun KM, Bulun SE
>Aromatase: a key molecule in the pathophysiology of endometriosis and a
>therapeutic target.
>Fertil Steril (United States), Dec 1999, 72(6) p961-9
>
>Zeitoun K, Takayama K, Michael MD, et al.
>Stimulation of aromatase P450 promoter (II) activity in endometriosis
>and its inhibition in endometrium are regulated by competitive binding
>of steroidogenic factor-1 and chicken ovalbumin upstream promoter
>transcription factor to the same cis-acting element.
>Mol Endocrinol (United States), Feb 1999, 13(2) p239-53
>
>Takayama K, Zeitoun K, Gunby RT, et al.
>Treatment of severe postmenopausal endometriosis with an aromatase
>inhibitor.
>Fertil Steril (United States), Apr 1998, 69(4) p709-13
>
>Noble LS, Simpson ER, Johns A, et al.
>Aromatase expression in endometriosis.
>J Clin Endocrinol Metab (United States), Jan 1996, 81(1) p174-9
>
>Dheenadayalu K, Mak I, Gordts S, et al.
>Aromatase P450 messenger RNA expression in eutopic endometrium is not a
>specific marker for pelvic endometriosis.
>Fertil Steril (United States), Oct 2002, 78(4) p825-9
>
>Gurates B, Sebastian S, Yang S, et al.
>WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and
>endometriotic stromal cells.
>J Clin Endocrinol Metab (United States), Sep 2002, 87(9) p4369-77
>
>Yang HJ, Shozu M, Murakami K, et al.
>Spatially heterogeneous expression of aromatase P450 through promoter II
>is closely correlated with the level of steroidogenic factor-1
>transcript in endometrioma tissues.
>J Clin Endocrinol Metab (United States), Aug 2002, 87(8) p3745-53
>
>Bulun SE, Gurates B, Fang Z, et al.
>Mechanisms of excessive estrogen formation in endometriosis.
>J Reprod Immunol (Ireland), May-Jun 2002, 55(1-2) p21-33
>
>Bulun SE, Yang S, Fang Z, et al.
>Estrogen production and metabolism in endometriosis.
>Ann N Y Acad Sci (United States), Mar 2002, 955 p75-85; discussion 86-8,
>396-406
>
>Bulun SE, Yang S, Fang Z, et al.
>Role of aromatase in endometrial disease.
>J Steroid Biochem Mol Biol (England), Dec 2001, 79(1-5) p19-25
>
>Kusuki I, Kitawaki J, Ishihara H, et al.
>Immunohistochemical localization of aromatase and apoptosis-associated
>proteins in ovarian serous cystadenocarcinoma arising from ovarian
>endometriosis.
>Eur J Obstet Gynecol Reprod Biol (Ireland), Sep 2001, 98(1) p114-8
>
>Ramachandran S, Song M, Murphy AA, et al.
>Expression of scavenger receptor class B1 in endometrium and
>endometriosis.
>J Clin Endocrinol Metab (United States), Aug 2001, 86(8) p3924-8
>
>Kitawaki J, Ishihara H, Koshiba H, et al.
>[Hormone responsiveness of endometriosis]
>Nippon Rinsho (Japan), Jan 2001, 59 Suppl 1 p70-6
>
>Kudoh M, Susaki Y, Ideyama Y, et al.
>Inhibitory effects of a novel aromatase inhibitor, YM511, on growth of
>endometrial explants and insulin-like growth factor-I gene expression in
>rats with experimental endometriosis.
>J Steroid Biochem Mol Biol (England), Sep-Oct 1997, 63(1-3) p75-80
>
>Kitawaki J, Noguchi T, Amatsu T, et al.
>Expression of aromatase cytochrome P450 protein and messenger
>ribonucleic acid in human endometriotic and adenomyotic tissues but not
>in normal endometrium.
>Biol Reprod (United States), Sep 1997, 57(3) p514-9
>
>Noble LS, Takayama K, Zeitoun KM, et al.
>Prostaglandin E2 stimulates aromatase expression in
>endometriosis-derived stromal cells.
>J Clin Endocrinol Metab (United States), Feb 1997, 82(2) p600-6
>
>Yano S, Ikegami Y, Nakao K
>Studies on the effect of the new non-steroidal aromatase inhibitor
>fadrozole hydrochloride in an endometriosis model in rats.
>Arzneimittelforschung (Germany), Feb 1996, 46(2) p192-5
>
>Harlow CR, Cahill DJ, Maile LA, et al.
>Reduced preovulatory granulosa cell steroidogenesis in women with
>endometriosis.
>J Clin Endocrinol Metab (United States), Jan 1996, 81(1) p426-9
>
>Frackiewicz EJ, Zarotsky V
>Diagnosis and treatment of endometriosis
>Expert Opin Pharmacother (England), Jan 2003, 4(1) p67-82
>
>Erbayraktar S, Acar B, Saygili U, et al.
>Management of intramedullary endometriosis of the conus medullaris.
>J Reprod Med (United States), Nov 2002, 47(11) p955-8
>
>Bulun SE, Zeitoun KM, Takayama K, et al.
>Estrogen biosynthesis in endometriosis: molecular basis and clinical
>relevance.
>J Mol Endocrinol (England), Aug 2000, 25(1) p35-42
>
>Bulun SE, Zeitoun K, Takayama K, et al.
>Estrogen production in endometriosis and use of aromatase inhibitors to
>treat endometriosis.
>Endocr Relat Cancer (England), Jun 1999, 6(2) p293-301
>
>Kitawaki J, Kusuki I, Koshiba H, et al.
>Expression of aromatase cytochrome P450 in eutopic endometrium and its
>application as a diagnostic test for endometriosis.
>Gynecol Obstet Invest (Switzerland), 1999, 48 Suppl 1 p21-8
>
>Sasano H, Harada N
>Intratumoral aromatase in human breast, endometrial, and ovarian
>malignancies.
>Endocr Rev (United States), Oct 1998, 19(5) p593-607
>
>Leyendecker G, Kunz G, Noe M, et al.
>Endometriosis: a dysfunction and disease of the archimetra.
>Hum Reprod Update (England), Sep-Oct 1998, 4(5) p752-62
>
>Vignali M, Infantino M, Matrone R, et al.
>Endometriosis: novel etiopathogenetic concepts and clinical
>perspectives.
>Fertil Steril (United States), Oct 2002, 78(4) p665-78
>
>Santen RJ
>To block estrogen's synthesis or action: that is the question.
>J Clin Endocrinol Metab (United States), Jul 2002, 87(7) p3007-12
>
>Kado N, Kitawaki J, Obayashi H, et al.
>Association of the CYP17 gene and CYP19 gene polymorphisms with risk of
>endometriosis in Japanese women.
>Hum Reprod (England), Apr 2002, 17(4) p897-902
>
>At Wed, 15 Jan 2003, dollbabi wrote:
>>
>>Can anyone give me a link to a current site for aromatase inhibitors? I
>>have been searching since last night and can only find sites from a few
>>years back.
>>Did they complete the study they were trying to get together or not?
>>>From what I can tell they have done 1 study with 1 woman. I even called
>>my gyn and the nurse called back and said that he doesn't know of anyone
>>using the aromatase inhibitors. I would like to find some current info
>>on this.
>> thanks,
>> Dollbabi
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