ENDO Messages for December, 2002: Re: how does endo affect implantation?

Re: how does endo affect implantation?

From: Anonymo (anonymous@obgyn.net)
Tue Dec 24 15:12:43 2002

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In reply to: holly: "how does endo affect implantation?"

Hi Holly. I just read the following, which might answer your question, that someone posted at the ERC forum:

Altered hormone levels behind infertility in endometriosis

Source: Human Reproduction 2002; 17: 960â??965

Prolactin and estradiol are implicated in study of endometriosis-associated infertility

Infertility in women who have endometriosis but no tubal blockages, may be caused by alterations in the secretion of the hormone prolactin and low estradiol levels in the blood, say researchers.

Infertile women who do not have endometriosis often have abnormally increased prolactin secretion in response to thyrotrophin-releasing hormone (TRH) or metoclopramide, a dopamine inhibitor, both of which act to increase prolactin secretion.

Dr. J. S. Cuhna-Filho and colleagues, from Universidade Federal do Rio Grande do Sul, Brazil, studied prolactin levels in 33 fertile women who did not have endometriosis, 10 fertile women who had minimal/mild endometriosis, and 21 infertile women who had endometriosis.

TRH or metoclopramide was administered to the women between days 3 and 5 in two menstrual cycles. Prolactin levels were measured beforehand, and again 15 and 30 minutes later.

Both fertile and infertile women with endometriosis had significantly higher levels of prolactin than those without endometriosis, both before and after TRH administration. Interestingly, metoclopramide had no effect on prolactin levels.

Women who had endometriosis and were infertile had significantly lower blood levels of estradiol than fertile women, regardless of whether they had endometriosis.

At Tue, 24 Dec 2002, holly wrote: >
>i'm jsut wondering about this because we've been ttc for about 7 years.
>i was just diagnosed with endo in nov. by my new ob/gyn. i have
>absolutely perfect tubes and ovaries, no adhesions, but endo in several
>lower spots including my cervix. i'm curious as to how this would
>affect my fertility. i don't think there is a problem getting the sperm
>to the egg, but is there a problem with implantation?
>
>i know hardly anything about endometriosis because i was told for so
>long that i just needed to deal with the pain. but i finally found a
>good doc who actually listens. wishing everyone pain-free days!
>holly
>
>--
>holly
>ttc for 7 years
>dx 1999 graves disease
>dx 2002 endometriosis
>

Next message: Kristy: "Re: How do you know what stage endo you have?"
Previous message: Kristy: "Re: Estrogen and cancer article"
In reply to: holly: "how does endo affect implantation?"

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