ENDO Messages for May, 2002: ATTN: JENNIFER! Read this article on Danazol Re: danazol and pregnancy

ATTN: JENNIFER! Read this article on Danazol Re: danazol and pregnancy

From: anonymous (anonymous@obgyn.net)
Sun May 12 00:49:12 2002

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In reply to: jennifer: "danazol and pregnancy"

Jennifer: Please get off of the Danazol immediately. The following article reports of a recent study which suggests that those who use Danazol are three times more likely to develop ovarian cancer. We endo sufferers are already at a 50% increased risk for development of ovarian cancer. http://www.pslgroup.com/dg/214df2.htm

GSPH: Danazol, Treatment For Endometriosis, Linked to Ovarian Cancer

PITTSBURGH, PA -- March 18, 2002 -- A commonly prescribed medication for treating endometriosis appears to elevate the risk ovarian cancer, according to findings presented by a University of Pittsburgh Graduate School of Public Health (GSPH) researcher at the 33rd annual meeting of the Society of Gynecologic Oncologists in Miami.

In the study, women taking danazol, a synthetic version of the male hormone androgen, were nearly three times more likely to develop ovarian cancer than were women taking leuprolide, an anti-androgenic, gonadotropin- releasing hormone agonist. Both drugs are used to treat endometriosis, a painful disease in which pieces of uterine tissue migrate to other parts of the body.

"Our previous studies have found that women with endometriosis are already at a 50-percent increased risk for ovarian cancer, and treating them with danazol appears to further increase their risk. This new result, even though it is preliminary, may factor into the equation when clinicians and their patients with endometriosis are deciding on the best treatment," said presenter Roberta B. Ness, M.D., M.P.H., associate professor of epidemiology at the GSPH and director of the school's Epidemiology of Women's Health Program.

The study analyzed pooled data from two case-control studies that examined the relationships among endometriosis, endometriosis treatments and ovarian cancer. Among women with endometriosis, 17 took danazol and 15 took leuprolide. Analysis showed that the study participants who took danazol were 2.7 times more likely to have ovarian cancer than were other women with endometriosis who did not take danazol. Women taking leuprolide had no significant elevation in risk.

"While the number of women studied is small, the results are telling, and they warrant further studies on a larger scale," said the study's principal investigator, Carrie Cottreau, Ph.D., assistant professor of obstetrics and gynecology, University of Pittsburgh School of Medicine. Additional research studies are planned at the University of Pittsburgh to further investigate the link between androgens and ovarian cancer.

Earlier this year, Dr. Ness and colleagues published results of a study showing that there is no association between fertility drugs and ovarian cancer. However, the study showed that the risk of ovarian cancer is 50 percent higher in women with endometriosis than it is for women without endometriosis.

At Sat, 11 May 2002, jennifer wrote: >
>Hi Ladies...
>Quick question. I'm on Danazol and have been since February. So far
>this has been the best thing i done for the endo pain. Of course it
>hasn't completely disappeared but it has definately decreased. Anyway,
>Danazol basically induces menopause and make your eggs dormant. Well,
>my question is, how is it possible to get pregnant on this medication.
>I'm not trying to get pregnant and i always use condoms but i just don't
>understand how it could happen. Maybe i don't completely understand
>what the med. really does or how the body reacts to it.
>I hope one of you will be able to help me with this.
>
>Pain free wishes angels!!
>
>--
>jennifer
>

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