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Endo? Check this out!From: anonymous (anonymous@obgyn.net)Wed May 2 20:54:44 2001
New message has been posted in the DIOXIN Conference Forum: Toxicology Thread: Dioxin toxicity? Author: Ing. Ferdinand O. Engelbeen Subject: Dioxin toxicity? URL: http://www.hygiene.ruhr-uni-bochum.de/dioxinconference/Index.cfm?Message_ID=666 A few years ago there was some discussion about the link between dioxin exposure and the prevalence of endometriosis in Belgium. Both dioxin exposure and number of endometriosis cases are the highest in the world. While there was a clear dose-response relation at high doses in Rhesus monkeys (but with a base line as high as 25%!), there were only indications that this was also the case for humans. But Prof. Konincks (Louvain) and the John Radcliffe Hospital (Oxford) didn't find a link between both in a large study. The USEPA financed a study amongst dioxin exposed women in the Seveso (Italy) accident. Finally, the summary of this study by Eskenazi on the Seveso dioxin-endometriosis link is now on the USEPA web site, see: http://es.epa.gov/ncer/final/grants/95/human/eskenazi.html The main conclusion: "There is extensive animal evidence suggesting effects of TCDD exposure on female reproductive endpoints, yet there is a lack of confirmation of these findings in large well-designed studies in humans. The ability to quantify individual level TCDD exposure from sera collected in 1976 for the Seveso cohort affords a unique opportunity to evaluate the potential dose-response relationship between TCDD exposure and a spectrum of reproductive endpoints in humans. To date, we have completed the endometriosis analysis. We found a doubled, non-significant, risk for endometriosis among women with serum TCDD levels of 100 ppt or higher, but no clear dose-response relation. There are a number of reproductive outcomes in the Seveso cohort for which data analysis is almost complete including breast cancer, menstrual cycle characteristics, birthweight of pregnancies conceived after 1976, and age of menarche. We expect next year to be highly productive, with great potential to provide result! s derived from a large, well-d No clear dose-response relationship means that some women with high levels of dioxin have not developed endometriosis, while others with low levels have the disease. Non-significant means that the relationship found (a doubling at high levels) can be the result of simply chance. Even if there was an established relationship in the Seveso population, that is not important for the general population, as the amounts are far lower than the intake which was found in Seveso (up to 56,000 times background!). With these results, it remains doubtful that there is any link between dioxin and endometriosis in humans at the todays background intake. It seems to me that other possible causes for endometriosis (PAH's?) should be investigated.... About dioxin intake: most is ingested by eating high fat animal food: fish and meat. If you reduce that, the intake will be (much) lower. Once in your body, it takes 7-10 years to halve the amounts. So they are very difficult to remove, once they are stored in your body fat. A diet which reduces the amount of body fat seems not helpfull, as the dioxins redistribute over the remaining fat reserves. The only way that may help is by eating non-edible fats, which change the distribution of dioxins from intake into removal. Once you have a disease like endometriosis, there is little that can be done to reverse that effect. Probably some hormone additions, which affect the oestrogen cycle, can reduce the side effects, but these will not help to stop the disease. Sincerely, Ferdinand Engelbeen
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